IMPROVED PHARMACEUTICAL COMPOSITION OF IBUPROFEN AND METHOD OF MAKING SUCH COMPOSITIONS

摘要

The active ingredient, ibuprofen or (s)(+)-ibuprofen as free base or as alkali metal salts or mixtures thereof, is covered by this invention in the form of soft gelatin capsule, said soft gelatin capsules have improved soft gelatin capsule gel mass composition which facilitates solubilization of active ingredient. The present invention also proposes the method of producing such a soft gelatin capsule or soft gelatin gel mass composition. One of the further aspects of the present invention is to avoid the use of polyethylene glycol or hydroxide ion species containing solvents as solubilizers for the preparation of soft gelatin capsules containing said active ingredient.