CDK-1 INHIBITOR OXINDOLES AND THE APPLICATION THEREOF IN THERAPEUTICS

摘要

The invention relates to a compound having formula (I): wherein R5 is selected from among groups 3-pyridinyl, 5-pyrimidinyl, C1-C4 -CONH-alkyl, C1-C4 -NHCO-alkyl, halogen, -CO2R, and R can be C1-C4 alkyl or hydrogen, -SO2NH2, -NO2, -CF3. Ar is selected from among groups 5-imidazolyl, 2-pyrrolyl optionally substituted by a C1-C4 alkyl radical, 2-furyl, or 2-thiazolyl, in form E, Z or a mixture of the two isomeric forms. Said invention can be used as a medicament for blocking proliferative cell division during the cycle and for inducing cell apoptosis for the treatment of primary and secondary cancerous tumours.