| 摘要 |
Inhibitors of MMP enzymes are cyclic sulfonamides of Formula I <SEE FORMULA I> or a pharmaceutically acceptable salt thereof, and cyclic sulfonamides of Formula III <SEE FORMULA III> III or a pharmaceutically acceptable salt thereof, wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 and R4 include hydrogen, halo, and alkyl; X is OH or NHOH. The compounds of Formulas I and III are useful for the treatment of diseases mediated by an M MP enzyme, including cancer, osteoarthritis, rheumatoid arthritis, heart failur e, and inflammation.
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