| 摘要 |
The present invention provides a process for the preparation of D-asparagine derivatives of formula Iwherein R1 is an amino protecting group and R2 is an alkyl, a substituted alkyl or a group of formula Awherein R3 is hydrogen or an lower alkyl group and n is 1, 2 or 3, which process comprises reacting a compound of formula IIwherein R1 and R2 are as defined above, with a protease in an aqueous solution at a pH of 6.0-7.5 and an organic solvent, and subsequently extracting the enantiomeric pure product of formula I. Compounds of formula I can be used as intermediates in the production of antibacterial substances.
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