| 摘要 |
<p>A geldanamycin derivative of general formula (I) and in vitro and in vivo methods of selectively inhibiting Hsp90 in a cell without substantially inhibiting Grp94 comprising administering to a cell comprising Hsp90 and Grp94, or to a host including cells comprising Hsp90 and Grp94, respectively, the geldanamycin derivative in an amount sufficient to inhibit Hsp90 without substantially inhibiting Grp94, as well as in vitro and in vivo methods of inhibiting HIF-1α in a cell comprising administering to a cell comprising HIF-1α the geldanamycin derivative in an amount sufficient to inhibit HIF-1α, and a method of treating or preventing cancer in a host comprising administering a geldanamycin derivative to a host in an amount sufficient to treat or prevent cancer.</p> |
