Compounds useful in therapy

摘要

Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R¹ represents C_1-4 alkyl; R² represents halo, C_1-4 alkyl, C_3-6 cycloalkyl, C_3-6 cycloalkyloxy, -SO₂(C_1-4 alkyl), optionally substituted C_1-4 alkyloxy, Het or -OHet; R³ represents a bicyclic group of the formula wherein X and Y are selected from C and N, provided that at least one is C; Ring A together with X and Y represents a 5- or 6-membered aromatic ring containing 0, 1, 2 or 3 nitrogen atoms in the ring; n is), 1 or 2 L represents a direct link, C_1-4 alkylene or C_1-4 alkoxyalkylene; R⁴ represents H, -NR⁵R⁶, C_3-6 cycloalkyl, -OR⁷, Het¹ or Het⁴; R⁵ and R⁶ are independently selected from H, C_3-6 cycloalkyl, C_3-6 cycloalkyl-C_1-4 alkylene, -SO₂(C_1-4 alkyl) and optionally substituted C_1-4 alkyl R⁷ is selected from H, C_1-4 alkyl, C_1-4 alkoxyalkyl, C_3-6cycloalkyl, Het² and C_1-4alkyl-Het³; R⁸ is H or C_1-4 alkyl; Het, Het¹, Het² and Het³ independently represent an optionally substituted 4 to 7 membered saturated heterocyclic group which may be mono- or bi-cyclic and which contains one or more heteroatoms selected from N, O or S; Het⁴ represents an optionally substituted 5 or 6 membered unsaturated heterocyclic group containing one or more heteroatoms selected from N, O or S; R⁹ is H or C_1-4 alkyl; R¹⁰ and R¹¹ are independently selected from H and C_1-4 alkyl; are useful in the treatment of hypertension, myocardial infarction, male erectile dysfunction (MED), hyperlipidaemia, cardiac arrhythmia, glaucoma and benign prostatic hyperplasia (BPH). They also find utility in the treatment of female sexual arousal dysfunction (FSAD).