| 摘要 |
Compounds of formula (I), a N-oxide form, a pharmaceutically acceptable addition salt or stereochemically isomeric form wherein; R1 is hydrogen, C1-6alkyl, aryl or C1-6alkyl substituted with aryl; R2 is each independently a halogen, hydroxy, C1-6alkyl, C1-6alkyloxy or nitro; N is 0, 1, 2 or 3; Alk is C1-6alkanediyl; D is a radical of formula (a), (b), (c), (d), (e) or (f) wherein; X each independently is O, S or NR12 R3 is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl; R4 is hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, amino, mono- or di(C1-6alkyl)amino or mono- or di(arylC1-6alkyl)amino; R5, R6, R7, R10, R11 and R12 each independently are hydrogen or C1-6alkyl R8 and R9 each independently are hydrogen, C1-6alkyl or aryl; or R4 and R5 taken together may from a bivalent radical -R4-R5- of formula (a-1), (a-2), (a-3), (a-4) or (a-5); wherein one or two hydrogen atom of said radicals (a-1) to (a-5) each independently may be replaced with halogen, C1-6alkyl, arylC1-6alkyl, trifluoromethyl, amino, hydroxy, C1-6alkyloxy or C1-10alkylcarbonyloxy; or where possible, two geminal hydrogen atoms my be replaced by C1-6alkylidene or arylC1-6alkylidene; or -R4-R5- may also be (a-6), (a-7), (a-8), (a-9), (a-10), (a-11), (a-12), (a-13) or (a-14); wherein one or where possible two or three hydrogen atoms in the radicals (a-6) to (a-14) each independently may be replaced by C1-6alkyl or aryl; and aryl is phenyl or phenyl substituted with halogen or C1-6alkyl. The tetrahydro g-carbolines produced are suitable for use in medicine.
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