ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODY COMPOSITIONS AND METHODS OF USE
摘要
The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
申请公布号
WO0140309(A3)
申请公布日期
2001.11.29
申请号
WO2000US29603
申请日期
2000.10.27
申请人
GENENTECH, INC.;DEVAUX, BRIGITTE;KELLER, GILBERT-ANDRE;KOEPPEN, HARTMUT;LASKY, LAURENCE, A.
发明人
DEVAUX, BRIGITTE;KELLER, GILBERT-ANDRE;KOEPPEN, HARTMUT;LASKY, LAURENCE, A.