COMBINATION PRODUCT COMPRISING A NON-STEROIDAL ANTIANDROGEN AND AN EGFR TYROSINE KINASE INHIBITOR

摘要

The invention concerns a combination therapeutic product comprising a non-steroidal antiandrogen and an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for use simultaneously, sequentially or separately in the synergistic treatment or prophylaxis of prostate cancer. In particular, the product of the invention is effective in inhibiting the transformation of prostate cancer cells from a hormone-dependent state into a hormone-independent state. It is further expected that the product of the invention will have a beneficial effect in preventing the onset of prostate cancer in men genetically predisposed to the disease.