| 摘要 |
<p>This invention provides isolated polynucleotides encoding an oncogenic osteomalacia-related factor and polypeptides encoded by this polynucleotide. Expression systems, including gene delivery vehicles such as liposomes and vectors, and host cells containing the polynucleotides are further provided by this invention. The present invention also provides proteins encoded by the polynucleotides and antibodies that specifically recognize and bind to these proteins. In one embodiment the proteins that modulate bone mineralization and phosphate metabolism as characterized by the methods described herein. The present invention also provides methods for modulating bone mineralization activity and phosphate metabolism and for treating diseases related to abnormal bone mineralization and abnormal phosphate metabolism.</p> |
