ISOLATION AND STRUCTURE OF SPONGISTATINS 5, 7, 8, AND 9

摘要

A Southwest Indian Ocean marine sponge Spirastrella spinispirulifera (bright colored reds and purples) has been found to contain new and exceptionally active cell (human cancer) growth inhibitors spongistatin 5, spongistatin 7, spongistatin 8 and spongistatin 9. These compositions are related to spongistatin 1, which was found in a black Spongier sp. in the Porifera family. A method of treating human cancer cells with spongistatin 5 and spongistatin 7 is also disclosed.