INTERFACE MEDIUM FOR TISSUE SURFACE PROBE

摘要

A composition useful as an interface medium to optically couple and facilitate contact between a probe and a tissue surface, such as skin, is described. Compositions of the present invention have an index of refraction of approximately 1.4, which approximates the indices of both the skin and the probe, and may be clear in the spectral region of 270-500 nm, pH buffered, slippery, water soluble and viscous. The compositions may also be used to calibrate the application of pressure between a probe and a surface and standardize operation of the instrument, or adjust the surface to optimize use of the instrument.