发明名称 |
Human fast-1 protein |
摘要 |
hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-beta receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-beta family. The invention includes tools for investigating the TGF-beta signaling pathway and screening for compounds which modulate the action of TGF-beta.
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申请公布号 |
US6225441(B1) |
申请公布日期 |
2001.05.01 |
申请号 |
US20000521109 |
申请日期 |
2000.03.07 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
ZHOU SHIBIN;ZAWEL LEIGH;VOGELSTEIN BERT;KINZLER KENNETH W. |
分类号 |
C07K14/47;C12N15/12;(IPC1-7):C07K7/00 |
主分类号 |
C07K14/47 |
代理机构 |
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