| 摘要 |
The invention relates to inhibitors of formula (I) of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms. In formula (I), each R<1> and R<2> is independently R<3>; R<8>; NHR<3>; NHR<5>; NHR<6>; NR<5>R<5>; NR<5>R<6>; SR<5>; SR<6>; SR<3>; OR<5>; OR<6>; OR<3>; C(O)R<3>; heterocyclyl optionally substituted with 1-4 independent R<4> on each ring; or C1-C10 alkyl substituted with 1-4 independent R<4>; R<3>, R<4>, R<5>, R<6>, R<8> are as defined in the application.
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| 申请人 |
KINETIX PHARMACEUTICALS INC.;ARMISTEAD, DAVID, M.;BEMIS, JEAN, E.;BUCHANAN, JOHN, L.;DIPIETRO, LUCIAN, V.;ELBAUM, DANIEL;HABGOOD, GREGORY, J.;KIM, JOSEPH, L.;MARSHALL, TERESA, L.;GEUNS-MEYER, STEPHANIE, D.;NOVAK, PERRY, M.;NUNES, JOSEPH, J.;PATEL, VINOD, F.;TOLEDO-SHERMAN, LETICIA, M.;ZHU, XIAOTIAN |
发明人 |
ARMISTEAD, DAVID, M.;BEMIS, JEAN, E.;BUCHANAN, JOHN, L.;DIPIETRO, LUCIAN, V.;ELBAUM, DANIEL;HABGOOD, GREGORY, J.;KIM, JOSEPH, L.;MARSHALL, TERESA, L.;GEUNS-MEYER, STEPHANIE, D.;NOVAK, PERRY, M.;NUNES, JOSEPH, J.;PATEL, VINOD, F.;TOLEDO-SHERMAN, LETICIA, M.;ZHU, XIAOTIAN |
