发明名称 |
IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES |
摘要 |
A compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid-3-yl or pyrazolo[2,3a]pyrid-3-yl; R2 is as defined within; m is 0-5; wherein the values of R2 may be the same or different; R1 is as defined within; n is 0 t o 2, wherein the values of R1 may be the same or different; Ring B is phenyl o r phenyl fused to a C5-7cycloalkyl ring; R3 is as defined within; p is 0-4; wherein the values of R3 may be the same or different; R4 is as defined within; q is 0-2; wherein the values of R4 may be the same or different; and wherein p+q<=5; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparatio n of compounds of formula (I) are detailed.
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申请公布号 |
CA2376293(A1) |
申请公布日期 |
2001.03.01 |
申请号 |
CA20002376293 |
申请日期 |
2000.08.15 |
申请人 |
ASTRAZENECA AB |
发明人 |
JEWSBURY, PHILLIP JOHN;BREAULT, GLORIA ANNE;THOMAS, ANDREW PETER;BEATTIE, JOHN FRANKLIN |
分类号 |
A61K31/437;A61K31/506;A61K31/5377;A61K31/63;A61P9/00;A61P9/10;A61P11/00;A61P13/12;A61P17/06;A61P19/08;A61P21/00;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P43/00;C07D221/00;C07D231/00;C07D235/00;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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