| 摘要 |
<p>Procedure for obtaining derivatives of 2-(2-pyridinilmethylsulphinyl) - 1H-benyimidazole of general formula (I), where R = H or analkyl radical; R'= Alkyl chain, which may or may not be interrupted by an atom of oxygen; R'= alkyl or alkoxy radical such as methyl and methoxy; R'''= H or alkoxy remnant which may or may not be substituted, characterised in that it is carried out by the replacement of an halogen in position '4' of the pyridine ring of the compounds of general formula (VIII) by an alkoxide in the presence of a base and within an aprotic polar solvent; or by replacement of a 'nitro' group in position '4' of the pyridine ring of the compounds of the compounds of formula (XVII) by an alkoxide radical R'O- in the presence of a base and within a mixture of solvents made up of the corresponding to alcohol R'OH and another aprotic polar solvent. It is useful for the treatment or prevention of gastric ulcers.</p> |
