| 摘要 |
<p>The invention relates to a new process for the synthesis of 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-3-acide derivatives of formula (I): wherein the meaning of Z is carboxyl or formyl group and to the new secoindoxylidene carboxylic acid derivatives of formula (II): wherein R?1 and R2¿ independently are C¿1?-C4 alkyl or alkoxy group, hydrogen or halogen atom - which are intermediates for preparing the compounds of formula (I). The 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-audrostane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one), which is used as anabolic in therapy.</p> |
