ANTAGONIST BLOCKADE OF CRF2 RECEPTORS FOR THE TREATMENT OF PSY CHIATRIC DISORDERS AND THE USE OF CHIMERIC ANTISENSE OLIGONUCLEOTIDES IN <i>IN VIVO</i> CNS STUDIES OF GENE FUNCTION

摘要

This invention relates to antisense oligonucleotides directed against the mRNA of the corticotropin releasing factor subtype-2 (CRF2) receptor which substantially reduce expression of CRF2 receptors in the rodent brain and the use of antisense oligonucleotides in in vivo CNS studies of gene function and to treat a wide range of psychiatric disorders including anxiety, obsessive-compulsive disorder, panic disorders, post-traumatic stress disorder, phobias and depression.