| 摘要 |
<p>A method of predicting susceptibility to HIV infection, or progression to AIDS after seroconversion, by detecting a polymorphism in the IL-10 promoter gene. In particular, the detected polymorphism is IL10-5'-592A, in which there is a transition from C to A at the -592 position in the IL10 promoter, which eliminates an ETS binding motif. Subjects who are either homozygous or heterozygous for the allele have a greater incidence of HIV seroconversion, and more rapid progression to AIDS, particularly more than 5 years after seroconversion. The polymorphism of the present invention can be used in association with other alleles, such as CCR5-Δ32, CCR5-P1, CCR2-641, SDF1-3'A, MBL and HLA-A, -B, and -C, to determine an individual's susceptibility to HIV infection, and provide a prognosis for disease progression in those who have been infected. The presence of the allele can also assist in the selection of more aggressive prophylactic or therapeutic treatment for individuals who are at greater risk for infection or disease progression.</p> |
