PEPTIDE VACCINE FOR CANINE ALLERGY

摘要

Disclosed is an isolated and purified peptide comprising a leucine positione d two peptide bonds away from a tyrosine-arginine pair, such as having the configuration: leucine-blank-blank-tyrosine-arginine, tyrosine-arginine-blan k- blank-leucine, or, leucine-blank-blank-tyrosine-arginine-blank-blank-leucine , where blank is any amino acid. Other peptides of the invention include those with the sequence cysteine-blank-blank-proline-histidine-blank-blank-blank- cysteine; cysteine-blank-proline-histidine-blank-proline-blank-blank-cystein e. The peptides can be linked to a carrier such as a multiply antigen protein o r a plant virus particle. Isolated and purified peptides of the invention can be used to induce canine autoantibodies directed to the canine igE molecule.