Hydrazide derivatives, process for their preparation and pharmaceutical compositions containing them

摘要

Hydrazide derivatives (I) are new. Hydrazide derivatives of formula (I) and their acid or base addition salts are new. n = 0 or 1; W' = -CO- or -S(O)r; r = 0-2; Z = aryl, aralkyl, heteroaryl or heteroaralkyl (all optionally substituted with 1-5 1-6C alkyl, 1-6c alkoxy, halo, OH, 1-6C perhalogenoalkyl, nitro, 1-6C acyl, 1-6C alkylsulfonyl or amino (optionally substituted with one or two 1-6C alkyl or 1-6C acyl)); R = Z-T-CO-, Z-O-T-CO-, Z-T-O-CO- or Z-T-S(O)r; T = bond, alkylene, alkenylene or alkynylene; A = 3-8C alkylene, 3-8C alkenylene, 3-8C alkynylene, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene or a group of formula (i); or A = forms a group of formula (ii) with the adjacent N; B1 = Z; B2 = 5 to 11-membered (un)saturated mono- or bicyclic ring optionally comprising 1-3 N, O or S; alkyl, alkylene = 1-6C; alkenylene, alkynylene = 2-6C; aryl, arylene = phenyl, naphthyl, dihydronaphthyl or tetrahydronaphthyl; heteroaryl = unsaturated or partially unsaturated 5- to 11-membered mono- or bicyclic ring containing 1-4 N,O or S; cycloalkylene = 4-8C; and provided that when n is 0, A is (i), B1 is benzyl, Z is phenyl (optionally substituted), then R is other than benzoyl. Independent claims are also included for: (1) the preparation of (I); and (2) pharmaceutical compositions comprising at leas one compound (I).