WATER SOLUBLE FLUORESCENT DYES FREE OF AGGREGATION AND SERUM BINDING AND RELATED PRODUCTS AND METHODS

摘要

The present invention thus relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products and methods for making such products. According to the present invention, detectably labeled marker components are provided that comprise a fluorophore moiety coupled to two or more small solubilizing axial ligands, [define] which preferably reduce or remove the problems of solvent sensitivity and non-specific binding.