| 发明名称 |
WATER SOLUBLE ANALOGS AND PRODRUGS OF PACLITAXEL |
| 摘要 |
The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1 = C(O)CH2CH(OH)COOX, R2 = H, C(O)CH2CH(OH)COOX, X = H , Li, Na or any other pharmaceutically acceptable counterion, as well as to a pharmaceutical composition comprising an antineoplastically effective amount of such analogs as an active ingredient.
|
| 申请公布号 |
CA2341234(A1) |
申请公布日期 |
2000.03.02 |
| 申请号 |
CA19982341234 |
申请日期 |
1998.08.21 |
| 申请人 |
PHARMACHEMIE B.V. |
发明人 |
DAMEN, ERIC WILHELMUS PETRUS;DE VOS, DICK;SCHEEREN, JOHAN WILHELM;WIEGERINCK, PETER HERMANUS GERARDUS;SPERLING, DUNCAN;BRAAMER, LESLY |
| 分类号 |
A61K31/335;A61K31/337;A61P35/00;C07D305/14;(IPC1-7):C07D305/14 |
主分类号 |
A61K31/335 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
