The invention is directed to mononucleosides and oligonucleotides that are conjugated to folic acid, related folates, antifolates and analogs thereof, and to non-nucleosidic folate conjugates. Methods for the preparation of nucleosidic and non-nucleosidic conjugates are also disclosed.
申请公布号
WO9966063(A2)
申请公布日期
1999.12.23
申请号
WO1999US13565
申请日期
1999.06.16
申请人
ISIS PHARMACEUTICALS, INC.;MANOHARAN, MUTHIAH;BHAT, BALKRISHEN;COOK, PHILLIP, DAN;GUZAEV, ANDREI, P.
发明人
MANOHARAN, MUTHIAH;BHAT, BALKRISHEN;COOK, PHILLIP, DAN;GUZAEV, ANDREI, P.
