| 摘要 |
PROBLEM TO BE SOLVED: To easily crystallize at low cost the subject compound usable as e.g. an antiinflammatory agent by recrystallization of an amorphous form of p-toluoylglucosyl diflucortolone with a solvent such as ethanol or (hydrous) 1-propanol. SOLUTION: This compound is easily obtained at low cost by recrystallization of an amorphous form of p-toluoylglucosyl diflucortolone 6α,9-difluoro-11β- hyclroxy-16a-methyl-21-[[2,3,4,6-tetrakis-O-(4-methylbenzoyl)-β-D- glucopyranosyl]oxyl-pregna-1,4-diene-3,20-dione} of formula I (p-Tol is p-toluoyl group of formula II) using one of the following solvents: ethanol, (hydrous) 1-propanol, 2-propanol-hydrous 2-butanol, (hydrous) 1-pentanol, (hydrous) 2- ethoxyethanol, and hydrous 2-methoxyethanol and the like.
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