发明名称 |
Human T-cell lymphotropic virus type I envelope protein and human monoclonal antibodies specific therefor |
摘要 |
Isolated and purified envelope protein of HTLV-I is provided devoid of non-envelope protein of HTLV-I and having substantially the same conformation as the envelope protein in native HTLV-I. The protein is produced recombinantly using a dual vaccinia/T7 polymerase system. Non-glycosylated and glycosylated forms of the protein are produced. Glycosylated forms are recognized by antibodies specific for the envelope protein of HTLV-I. Monoclonal antibodies are provided which are specific for the HTLV-I envelope protein and non-binding to HTLV-I envelope protein in denatured form. The HTLV-I envelope protein is cross-reactive with antibodies of HTLV-II and STLV. The envelope protein is useful in diagnosis of infection by HTLV-I and HTLV-II.
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申请公布号 |
US5961984(A) |
申请公布日期 |
1999.10.05 |
申请号 |
US19960626452 |
申请日期 |
1996.04.02 |
申请人 |
UNIVERSITY OF WESTERN ONTARIO;STANFORD UNIVERSITY |
发明人 |
DEKABAN, GREGORY A.;ARP, JACQUELINE;FOUNG, STEVEN KOK HING |
分类号 |
A61P31/18;C07K14/15;C07K16/10;(IPC1-7):A61K39/21;A61K39/42;C12Q1/70;A23J1/00 |
主分类号 |
A61P31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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