Oligonucleotides having a conserved G4 core sequence

摘要

PCT No. PCT/US93/09297 Sec. 371 Date Jun. 12, 1995 Sec. 102(e) Date Jun. 12, 1995 PCT Filed Sep. 29, 1993 PCT Pub. No. WO94/08053 PCT Pub. Date Apr. 14, 1994Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnosis and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to plat a role in the aging process of a cell and in control of malignant cell growth.