| 摘要 |
<p>The present invention termed 'inverse screening' provides a method to identify and isolate molecules that specifically and selectively recognise proteins - these molecules being called 'protein affinity ligands'. The method enables 'protein affinity ligands' to be obtained not only for proteins of known identity but also those where prior knowledge or access to the individual proteins for which the 'protein affinity ligands' are isolated were not available. Moreover, the method can be used in a targeted process whereby 'protein affinity ligands' for a protein of interest - that may or may not be available in purified form and may or may not be of previously known identity - are generated and identified. Alternatively, the method can be used in a shotgun process whereby 'protein affinity ligands' to multiple proteins are generated and isolated simultaneously. Again, this may be achieved without requiring access to the individual proteins or indeed prior knowledge of their identity.</p> |
