发明名称 |
Solvent dried polysaccharide sponges |
摘要 |
The invention provides a method of preparing water-insoluble polysaccharide sponges, and sponges obtained by means of the method. The method comprises: (a) providing an aqueous solution of a soluble polysaccharide; (b) freezing the solution; (c) treating the frozen solution with a water-miscible organic solvent such as isopropanol to effect solvent exchange for the water in the frozen solution; and (d) drying the resulting polysaccharide material. The organic solvent contains a cross-linking agent such as calcium chloride to render the polysaccharide water-insoluble in the solvent-exchange step (c). The resulting materials are more conformable and less friable than freeze-dried polysaccharide sponges.
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申请公布号 |
US5888987(A) |
申请公布日期 |
1999.03.30 |
申请号 |
US19970963106 |
申请日期 |
1997.11.03 |
申请人 |
JOHNSON & JOHNSON MEDICAL, INC. |
发明人 |
HAYNES, CARLA ANNE;LORIMER, ELAINE |
分类号 |
A61L15/16;C08J3/24;C08J9/26;C08J9/28;C08L1/00;(IPC1-7):A61K31/715;A61F13/00 |
主分类号 |
A61L15/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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