摘要 |
Compounds of formula (I): <IMAGE> (I) [wherein: X represents an optionally substituted benzimidazole group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethlyl group; R represents hydrogen, alkyl, alkoxy, halogen, hydroxy, nitro, amino or aralkyl; and m is an integer from 1 to 5]; have valuable activity for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistance and diabetic complications.
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申请人 |
SANKYO COMPANY, LIMITED |
发明人 |
FUJITA, TAKASHI;WADA, KUNIO;OGUCHI, MINORU;YANAGISAWA, HIROAKI;FUJIMOTO, KOICHI;FUJIWARA, TOSHIHIKO;HORIKOSHI, HIROYOSHI;YOSHIOKA, TAKAO |