发明名称 |
THERAPEUTIC NANOSPHERES |
摘要 |
4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized within the cell. In addition, it appears to cause cells to developmentally differentiate. The present invention provides nanosphere formulations of 4-phenylbutyrate and other drugs which remediate defective protein localization intracellularly. These formulations permit lower concentrations of drugs to be administered, providing both cost and safety benefits.
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申请公布号 |
CA2303268(A1) |
申请公布日期 |
1998.12.17 |
申请号 |
CA19982303268 |
申请日期 |
1998.06.11 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
WALSH, SCOTT;RUBENSTEIN, RONALD;ZEITLIN, PAMELA;LEONG, KAM |
分类号 |
A61K9/51;A61K31/19;A61K31/192;A61K31/352;A61K31/435;A61K31/52;A61K45/06;A61K47/30;A61K47/36;A61K47/42;A61K47/48;A61K48/00;A61P7/00;A61P11/00;A61P35/00;A61P43/00;(IPC1-7):A61K31/19 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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