Serine derivative

摘要

PCT No. PCT/JP94/00697 Sec. 371 Date Oct. 12, 1995 Sec. 102(e) Date Oct. 12, 1995 PCT Filed Apr. 26, 1994 PCT Pub. No. WO94/25450 PCT Pub. Date Nov. 10, 1994A serine derivative represented by the general formula (I) <IMAGE> (I) (symbols in the formula represent the following meanings; X: a sulfur atom or an oxygen atom, Y: a nitrogen atom or CH, R1 and R2: the same or different from each other and each represents a hydrogen atom, a lower alkyl group or a protecting group for the amino group, or R1 and R2 may be combined together to form a four- to nine-membered nitrogen-containing cycloalkyl group, R3: a hydrogen atom, a carboxyl group, a protected carboxyl group, an aralkyl group, or a lower alkyl group unsubstituted or substituted with a hydroxyl group, R4: a hydrogen atom or a hydroxyl group, R5: a hydrogen atom or a lower alkyl group, A: a lower alkylene group, B: 1) a saturated or unsaturated four- to ten-membered nitrogen-containing cycloalkyl group unsubstituted or substituted with a lower alkyl group or an aralkyl group or 2) a bicyclic nitrogen-containing hydrocarbon ring radical resulting from the condensation of a four- to eight-membered nitrogen-containing cycloalkyl group with a benzene ring, and +E,uns . . .+EE : a single or double bond) or a pharmaceutically acceptable salt thereof, which has an anti-PCP (phencyclidine) action and is useful as a psychotropic drug.