| 摘要 |
A pharmaceutical compound of the formula <CHEM> in which R<1> and R<2> are each hydrogen, C1-4 alkyl, C1-4 alkoxy, HO-C1-4 alkyl, C1-4 alkoxy-C1-4 alkyl, C1-4 alkylthio, halo or phCR'R"- where Ph is optionally substituted phenyl and R' and R" are each hydrogen or C1-4 alkyl, or R<1> and R<2> together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, R<3>, R<4> and R<5> are each hydrogen, halo, nitro, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkyl-CO-, C1-4 alkyl-S(O)m-where m is 0, 1 or 2, R'R"N-SO2-, -COOR', -CONR'R", -NR'R", -N(OR')COOR", -COR', -NHSO2R', where R' and R" are each hydrogen or C1-4 alkyl, R<6> and R<7> are each hydrogen or C1-4 alkyl, and n is 1 to 6, X is oxygen or sulphur, W is <CHEM> where p is 4 to 7, and q and r are each 1 to 3, Y is &rdurule& CO or -CH(OH)-, and Z is optionally substituted phenyl or optionally substituted heteroaryl; and salts and esters thereof. |
