| 摘要 |
<p>A photocleavable cyclic oligonucleotide having a base sequence capable of hybridizing with a target DNA or RNA and a structure cyclized with a photocleavable linkage. The oligonucleotide is not decomposed by nucleases in the living body owing to its cyclic structure, so that it can be diffused to predetermined positions in the body by taking a sufficiently prolonged time. Further, the linkage is cleaved by irradiation with a suitable light after the lapse of a predetermined time, by which the cyclic oligonucleotide is converted into a linear one, thus acting as an antisense oligonucleotide.</p> |
