| 摘要 |
<p>Disclosed are organo phosphonic acids having formula (I) where: n = 0 or 1; R1 = H or (a); R2 = (b) or (c); R3 = an alkyl group containing > 10 carbon atoms; and R4 = H or CH3, that provide improved bio-availability of drugs and nutrients by permiabilising cell membranes. The products are prepared by the method of reacting an acid chloride of long chain aliphatic acid having 10-20 carbon atoms with an alkyl phosphonic acid derivative containing an active amino or hydroxy group in chloroform at temperatures below 5 °C. Especially useful are the reaction products of palmitoyl or lauroyl chloride with ethane-1-hydroxy-1,1-diphosphonic acid, 2-amino-ethyl phosphonic acid or 1-amino-ethyl phosphonic acid.</p> |
