| 摘要 |
The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection. |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECTRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, WASHINGTON, D.C., US |
发明人 |
BOYD, MICHAEL, R., IJAMSVILLE, MD 21754, US;CARDELLINA, JOHN, H., II, WALKERSVILLE, MD 21793, US;GUSTAFSON, KIRK, R., MT. AIRY, MD 21771, US;DECOSTERD, LAURENT, A., CH-1260 NYON, CH;PARSONS, IAN, ITHACA, NY 14850, US;PANNEL, LEWIS, SILVER SPRING, MD 20802, US;MCMAHON, JAMES, B., FREDERICK, MD 21701, US;CRAGG, GORDON, M., BETHESDA, MD 20814, US |
