发明名称 |
1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-SUBSTITUTED PIPERAZINE DERIVATIVES |
摘要 |
<p>This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; p is 1 or 2; =Q is =O or =NR<3>; X is a covalent bond or a bivalent radical of formula -O-, -S-, -NR<3>-; R<1> is Ar<1>, Ar<1>C1-6alkyl or di(Ar<1>)C1-6alkyl, wherein each C1-6alkyl group is optionally substituted with hydroxy, C1-4alkyloxy, oxo or a ketalized oxo substituent; R<2> is Ar<2>, Ar<2>C1-6alkyl, Het<1> or Het<1>C1-6alkyl; R<3> is hydrogen or C1-6alkyl; L is hydrogen; Ar<3>; C1-6alkyl; C1-6alkyl substituted with 1 or 2 substituents selected from hydroxy, C1-6alkyloxy, Ar<3>, Ar<3>C1-6alkyloxy and Het<2>; C3-6alkenyl; Ar<3>C3-6alkenyl; di(Ar<3>)C3-6alkenyl or a radical of formula (a-1), (a-2), (a-3), (a-4) or (a-5); Ar<1>, Ar<2> and Ar<3> are each phenyl or substituted phenyl; Het<1> and Het<2> are each monocyclic or a bicyclic heterocycle; as substance-P antagonists; their preparation, compositions containing them and their use as a medicine.</p> |
申请公布号 |
WO9716440(A1) |
申请公布日期 |
1997.05.09 |
申请号 |
WO1996EP04660 |
申请日期 |
1996.10.25 |
申请人 |
JANSSEN PHARMACEUTICA N.V.;JANSSENS, FRANS, EDUARD;SOMMEN, FRANCOIS, MARIA;SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAINE;LEENAERTS, JOSEPH, ELISABETH;VAN ROOSBROECK, YVES, EMIEL, MARIA |
发明人 |
JANSSENS, FRANS, EDUARD;SOMMEN, FRANCOIS, MARIA;SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAINE;LEENAERTS, JOSEPH, ELISABETH;VAN ROOSBROECK, YVES, EMIEL, MARIA |
分类号 |
C07D401/04;A61K31/00;A61K31/495;A61K31/496;A61K31/4965;A61K31/497;A61K31/498;A61P1/08;A61P23/00;A61P29/00;A61P37/02;A61P37/08;A61P43/00;C07D211/58;C07D401/12;C07D401/14;C07D405/06;C07D405/12;C07D405/14;C07D409/06;C07D409/14;C07D413/06;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D471/04;C07D471/14;(IPC1-7):C07D401/04 |
主分类号 |
C07D401/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|