发明名称 |
ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY |
摘要 |
A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, adenoviral expression vectors are provided that contain a K-ras nucleic acid positioned antisense to regulatory control regions. In one embodiment, the adenoviral expression vector is a replication-deficient adenoviral vector lacking the E1 region and containing a K-ras nucleic acid. Also provided are methods for the inhibition of cancer cell proliferation.
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申请公布号 |
WO9716547(A1) |
申请公布日期 |
1997.05.09 |
申请号 |
WO1996US17979 |
申请日期 |
1996.10.31 |
申请人 |
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYST |
发明人 |
ROTH, JACK, A.;ALEMANY, RAMON;ZHANG, WEI-WEI;MUKHOPADHYAY, TAPAS |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C12N15/11;C12N15/86;A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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