Ribozyme-mediated inhibition of bovine leukemia virus

摘要

A ribozyme is provided which is capable of cleaving bovine leukemia virus (BLV) RNA both in a cell free system and intracellularly. The ribozyme of the present invention comprises the hammerhead motif flanked by antisense sequences complementary to BLV rex/tax RNA. Introduction of the ribozyme into BLV-infected cells results in inhibition of BLV protein expression, allowing for the control of BLV infection.