OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS

摘要

Oxygen-containing heterocyclic compounds represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, lower alkyl, cyano or -(CH2)n-E-CO-F (wherein E represents a bond, O or NH; F represents OR6 or NR7R8; and n is an integer of from 0 to 4), or R1 and R2 together with the adjacent carbon atom may form a saturated carbocyclic ring, or R2 together with R11 or R13, as will be described hereinbelow, may form a single bond; R3 represents hydrogen, phenyl or halogeno; R4 represents hydroxy, lower alkoxy, etc.; A represents C(R9)(R10)- or O; B represents O, NR11, -C(R12)(R13)- or -C(R14)(R15)-C(R16)(R17)-; D represents (1) -C(R18)(R19)-X- ¢where X represents C(R21)(R22)-, S or NR23!, (2) -C(R19a)=Y- ¢wherein Y represents -C(R24)-Z-, {wherein Z represents CONH, CONHCH2 or a bond}, or N! or (3) a bond; and R5 represents aryl, heteroaryl, cycloalkyl, pyridine-N-oxide, cyano or lower alkoxycarbonyl.