| 摘要 |
<p>The invention refers to the use of Lactobacillus plantarum having a mannose-specific adhesin for the preparation of a pharmaceutical composition inhibiting the binding of pathogenic bacteria expressing mannose-specific adhesins to the epithelial cell surface. A strain of Lactobacillus plantarum which can be used in the invention adheres to D-mannose-coated agarose beads, and preferably belongs to a cluster of L. plantarum with more than 70 % similarity to L. plantarum 299 in terms of REA. The invention also refers to the use of said strains for the preparation of a pharmaceutical composition to be used in prophylatic and/or curative treatment of bacterial translocation, gastroenteritis and other diseases caused by pathogenic bacteria expressing mannose-specific adhesins.</p> |
