DIPHENYL-2-PIPERIDINONE AND -2-PYRROLIDINONE DERIVATIVES HAVING ANTI-CONVULSANT AND NEUROPROTECTIVE ACTIVITY

摘要

Compounds of formula (I), wherein two of R<1>, R<2>, R<3> and R<4> independently represent phenyl optionally substituted by one or more groups selected from halogen, hydroxy, nitro, amino, C1-6alkyl and C1-6alkoxy; and the ramainder of R<1>, R<2>, R<3> and R<4> independently represent hydrogen or C1-6alkyl; R<5> and R<6> independently represent hydrogen, C1-6alkyl or C3-6cycloalkyl, or R<5> and R<6> together with the nitrogen atom to which they are attached form a C4-6N heterocycle; m is 1 or 2; and n is 1, 2 or 3; and pharmaceutically acceptable acid addition salt thereof; are useful in the treatment of neurodegenerative disorders, particularly epilepsy.