| 摘要 |
<p>The invention provides materials and methods for cell control and suppression, in particular for the control and suppression of cells involved in immune responses such as those already established against an allergen. The invention provides use of a water soluble complex of (i) one or more non-immunogenic water-soluble polymers; and (ii) a ligand for a moiety on the surface of a target cell in the preparation of a medicament for administration to a patient in order to prevent or alleviate symptoms of a medical condition, which symptoms are determined by an activity of said target cell which may be altered by the binding of said complex to the cell membrane of said target cell via an interaction between said ligand and cell surface moiety. The polymer is typically a poly(alkylene glycol). The invention is particularly appropriate to the alleviation of granulocyte-mediated symptoms of an existing IgE antibody immune response against an environmental allergen.</p> |
