| 摘要 |
NOVEL BIOREDUCTIVE COMPOUNDS A quinoxaline or pyridopyrazine derivative of formula (I) (I) wherein R1 is a group containing a hydroxyl, oxiranyl, aziridine, alkylamino, pyrrolidino, morpholine, piperidino, piperazino, 2-nitroimidazolyl, or 5-nitrofuryl group; R2 is a hydrocarbyl, or heterocyclyl aromatic group unsubstituted or substituted by one or more substituents selected from halogen haloalkyl, alkyl, nitro, hydroxy, alkoxy and alkylenedioxy; The groups R3 are the same or different and each is hydrogen, alkyl, or hydroxy; X is -CH= or -N=, and X1 in hydrogen or halogon; and pharmaceutically acceptable salts thereof are useful in the treatment of tumours, and in particular hypoxic tumours. Processes for producing the compound and pharmaceutical compositions containing them.
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