发明名称 |
PROCESS FOR PREPARING GRANULATION OF DRUG USING COVALENT BOND BETWEEN DRUG AND POLYMER |
摘要 |
A process for preparing controlled release microsphere comprises: (a) adding drug into the polymer soln.; (b) reacting it in the presence of chemical catalyst to form the drug-polymer covalent complex (I); (c) suspending the obtd. (I) in the organic solvent to obtain the emulsified soln.; (d) hardening the (I) by heating at 80-170 deg.C or reacting the emusified soln. chemically; (e) replacing the surface of (I) with polr radical and centrifuging to obtain the precipitate; (f) washing the precipitate and freeze-drying to obtain the final product. The polymer is protein (e.g. serum albumin), sythetic polypeptide (e.g. poly-L-glutamic acid) or polysaccaride (e.g. dextran). The obtd. microsphere is useful as medicine, food additive etc.
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申请公布号 |
KR920003166(B1) |
申请公布日期 |
1992.04.23 |
申请号 |
KR19870013775 |
申请日期 |
1987.12.03 |
申请人 |
KIM, CHONG - KUK;OH, YU - KYUNG |
发明人 |
KIM, JONG - KUK |
分类号 |
A61K9/50;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/50 |
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主权项 |
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地址 |
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