| 摘要 |
The invention relates to a new way for guiding a pharmaceutical to specific targets such as microorganisms as bacteria and viruses, tissue cells or tumor cells. The mechanism of targeting is characterized by a number of weakly interacting sites - Kass < ca 10<4> M<-1> - which by cooperation can realize a strong and specific binding to the target which can be e.g. surface antigens on bacteria, viruses or tumor cells. Alternatively the target can be structures of the host cell which can interact with the foreign substance. This weak affinity pharmaceutical can act in different ways by preventing and blocking the binding of the microorganism/tumor cell to its target, host cell or by an improved targeting of the pharmaceutical to the specific binding place. The pharmaceutical system is generally composed of a number of weak affinity sites that is defined and with a specific configuration that a binding to the target is achieved. The combination of affinity sites is obtained by various carriers such as microparticulate substances, macromolecules and low molecular weight substances. In addition, substances are included such as cell poisons, which are used to destroy the invading microorganism/tumor cell. |
