NOVEL PEPTIDE AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR

摘要

NEW MATERIAL:A compound expressed by the formula and salts thereof. USE:An angiotensin converting enzyme inhibitor useful for treating or preventing hypertension with ultrahigh safety. PREPARATION:For example, a peptide synthesizer is charged with Boc-L-Pro-O- CH2-phenylacetamidomethyl resin (Boc is tert-butyloxycarbonyl) and Boc-L-pro, Boc-L-Leu, Boc-L-His(Tos) (Tos is tosyl) and Boc-L-Val and the compound expressed by the formula is synthesized in the presence of dicyclohexylcarbodiimide by an anhydrous symmetric method.