METHOD FOR PRODUCTION OF 1,3,2-DIOXAPHOSPHOLES

摘要

of the disclosure The invention relates to a method of producing a 1,3,2-dioxaphosphole of the formula ¢I!B ¢I! B wherein represents a benzene ring which may be substituted and R represents an aryl, alkoxy or aralkyloxy group which may be substituted, which comprises reacting a catechol compound of the formula ¢II!B ¢II!B wherein is as defined above, with a compound of the formula ¢III!B ¢III!B wherein X is a halogen atom and R is as defined above, at a temperature not higher than about 30.degree.C in the presence of a base. The compounds of formula ¢I!B are useful, for example, as neutral catalysts in deriving cephalosporin antibiotics, which have important value in the treatment of bacterial diseases.