| 摘要 |
PURPOSE: To obtain an injectable sustained release preparation by dispersing a polypeptide substance at an effective level in a support containing a base consisting of natural or synthetic oil, fatty acid salt and/or absorption-controlling agent. CONSTITUTION: This somatotropin preparation is obtained by dispersing a polypeptide substance (esp. bovine somatotropin) at an effective concentration in a support containing an absorbable biocompatible base consisting of natural or synthetic oil, a fatty acid salt (e.g. calcium stearate) and/or an absorption- controlling agent (e.g. dextran). The bovine somatotropin is pref. in the form of fine granules (50-500μm in size); accounting for 5-45 (pref. 15-30)wt.% of this preparation, and the oil component pref. accounts for >=30 (pref. 30-70)wt.% of this preparation. In the case of combined use of the fatty acid salt with the absorption-controlling agent, the weight ratio of the former to the latter is (1:95) to (95:1) [esp. (1:1) to (3:1)].
|
