| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I {R is OH, alkoxy, -COOR<1> [R<1> is H, (substituted)1-6C alkyl, aralkyl or aryl] or -CH(NHR<2>)COOR<3> [R<2> is H or monofunctional amino-protecting group; R<3> is H, (substituted)1-6C alkyl, aralkyl or aryl]; n is 0-3}. EXAMPLE:3'-N-(5-Methoxysalicylidene)-4'-O-tetrahydropyranyladriamycin. USE:An antitumor agent. PREPARATION:A free base of 4'-O-tetrahydropyranyladriamycin expressed by formula II is dissolved in an organic solvent and a salicylaldehyde derivative expressed by formula III is added to the resultant so and reacted therewith at ambient temperature or while being heated.</p> |
